/* ==========================================================================
   药物研发知识库 · 设计系统
   主题：证据可追溯。排版基调=学术文献，动效只保留一次开场与少数交互反馈。
   色板：1F4D9A 深蓝 / 3879C9 主蓝 / B7D2E8 浅蓝
   ========================================================================== */

:root{
  --navy:#1F4D9A;
  --blue:#3879C9;
  --sky:#B7D2E8;
  --ink:#16233A;
  --muted:#64748B;
  --faint:#93A2B5;
  --hair:#DDE6F0;
  --paper:#FCFDFE;
  --wash:#F3F7FB;
  --white:#FFFFFF;

  --serif:"Source Han Serif SC","Noto Serif SC","Songti SC",SimSun,serif;
  --sans:-apple-system,BlinkMacSystemFont,"Segoe UI","PingFang SC","Hiragino Sans GB","Microsoft YaHei",sans-serif;
  --mono:"SF Mono",Consolas,"Courier New",monospace;

  --t-hero:clamp(34px,5.4vw,66px);
  --t-h2:clamp(24px,2.7vw,34px);
  --t-body:15.5px;
  --t-sm:13.5px;

  --ease:cubic-bezier(.22,.61,.36,1);
  --ease-out:cubic-bezier(.16,1,.3,1);
}

*,*::before,*::after{box-sizing:border-box}
html{-webkit-text-size-adjust:100%}
html,body{overflow-x:hidden}
body{
  margin:0;background:var(--paper);color:var(--ink);
  font-family:var(--sans);font-size:var(--t-body);line-height:1.75;
  -webkit-font-smoothing:antialiased;
}
::selection{background:rgba(56,121,201,.16)}
a{color:inherit;text-decoration:none}
img{max-width:100%;display:block}
button{font:inherit;cursor:pointer;background:none;border:0;color:inherit}
:focus-visible{outline:2px solid var(--blue);outline-offset:3px}

/* ------------------------------ 布局 ------------------------------ */
.wrap{width:min(1180px,calc(100% - 56px));margin-inline:auto;position:relative}
.section{padding:88px 0}
.section + .section{padding-top:0}
.section-head{
  display:flex;align-items:baseline;justify-content:space-between;gap:32px;
  margin-bottom:38px;
}
.section-head h2{
  font-family:var(--serif);font-size:var(--t-h2);line-height:1.3;
  letter-spacing:-.01em;margin:0;font-weight:600;
}
.section-head p{color:var(--muted);font-size:var(--t-sm);margin:0;max-width:36ch;text-align:right;line-height:1.7}
/* 段落小标签：小写、不描边、不占视觉主角 */
.eyebrow{
  font-size:12px;color:var(--muted);margin:0 0 10px;
  letter-spacing:.02em;
}
.crumb{padding:24px 0 0;font-size:12.5px;color:var(--faint)}
.crumb a{color:var(--muted);transition:color .18s var(--ease)}
.crumb a:hover{color:var(--navy)}
.crumb span{color:var(--faint)}
.loading{display:flex;gap:6px;justify-content:center;padding:120px 0}
.loading .dot{width:5px;height:5px;border-radius:50%;background:var(--sky);animation:b 1.1s infinite}
.loading .dot:nth-child(2){animation-delay:.14s}
.loading .dot:nth-child(3){animation-delay:.28s}
@keyframes b{0%,80%,100%{opacity:.35;transform:translateY(0)}40%{opacity:1;transform:translateY(-5px)}}
.empty{padding:52px 0;text-align:center;color:var(--faint);font-size:var(--t-sm);border-top:1px solid var(--hair)}
.note{font-size:12.5px;color:var(--muted);line-height:1.8}
.prose{font-size:15px;line-height:1.95;color:#2A3A55;max-width:76ch}

/* ------------------------------ 顶栏 ------------------------------ */
.topbar{
  position:sticky;top:0;z-index:100;
  background:rgba(252,253,254,.9);
  backdrop-filter:saturate(180%) blur(12px);
  -webkit-backdrop-filter:saturate(180%) blur(12px);
  border-bottom:1px solid transparent;
  transition:border-color .3s var(--ease),box-shadow .3s var(--ease);
}
.topbar.scrolled{border-bottom-color:var(--hair)}
.topbar-inner{
  width:min(1260px,calc(100% - 48px));margin-inline:auto;
  display:flex;align-items:center;gap:20px;height:74px;
  transition:height .3s var(--ease);
}
.topbar.scrolled .topbar-inner{height:64px}
.orgs{display:flex;align-items:center;gap:12px;flex:none}
.org{height:40px;width:auto;transition:height .3s var(--ease)}
.topbar.scrolled .org{height:34px}
.org-sep{width:1px;height:28px;background:var(--hair)}
.brand{display:flex;align-items:center}
.brand-text{display:flex;flex-direction:column;line-height:1.25;border-left:1px solid var(--hair);padding-left:15px}
.brand-text strong{font-family:var(--serif);font-size:16px;letter-spacing:.01em;white-space:nowrap}
.brand-text em{font-style:normal;font-size:9.5px;color:var(--faint);letter-spacing:.08em;white-space:nowrap}

.nav{display:flex;align-items:center;gap:4px;margin-left:auto}
.nav a{
  position:relative;padding:6px 11px;font-size:13.5px;color:var(--muted);
  transition:color .18s var(--ease);
}
.nav a::after{
  content:"";position:absolute;left:11px;right:11px;bottom:0;height:1px;
  background:var(--navy);transform:scaleX(0);transform-origin:left;
  transition:transform .34s var(--ease-out);
}
.nav a:hover{color:var(--ink)}
.nav a:hover::after{transform:scaleX(1)}
.nav a.active{color:var(--navy);font-weight:600}
.nav a.active::after{transform:scaleX(1)}

.search{position:relative;display:flex;align-items:center;flex:none}
.search-icon{
  position:absolute;left:11px;width:13px;height:13px;fill:none;stroke:var(--faint);
  stroke-width:1.6;stroke-linecap:round;pointer-events:none;transition:stroke .18s;
}
.search input{
  width:200px;height:36px;padding:0 14px 0 32px;
  border:1px solid var(--hair);background:var(--white);border-radius:2px;
  font-size:13px;color:var(--ink);outline:none;
  transition:width .3s var(--ease),border-color .2s;
}
.search input::placeholder{color:var(--faint)}
.search input:focus{width:250px;border-color:var(--blue)}
.search:focus-within .search-icon{stroke:var(--blue)}
.search button{display:none}
.search-kbd{display:none}
.nav-toggle{display:none;width:40px;height:40px;padding:8px}
.nav-toggle span{display:block;height:1.5px;background:var(--ink);margin:5px 0;transition:transform .3s var(--ease)}
.nav-toggle[aria-expanded="true"] span:first-child{transform:translateY(3.2px) rotate(45deg)}
.nav-toggle[aria-expanded="true"] span:last-child{transform:translateY(-3.2px) rotate(-45deg)}

/* ------------------------------ 按钮 ------------------------------ */
.btn{
  display:inline-flex;align-items:center;justify-content:center;gap:6px;
  height:42px;padding:0 20px;background:var(--navy);color:#fff;
  font-size:13.5px;letter-spacing:.01em;border:1px solid var(--navy);border-radius:1px;
  transition:background .2s var(--ease),border-color .2s var(--ease),color .2s var(--ease);
}
.btn:hover{background:#173C7C;border-color:#173C7C}
.btn.ghost{background:transparent;color:var(--ink);border-color:var(--hair)}
.btn.ghost:hover{background:var(--wash);border-color:var(--sky);color:var(--navy)}
/* 文字链接：下划线生长，不加箭头符号 */
.link{
  display:inline-block;font-size:13.5px;color:var(--navy);padding-bottom:2px;
  background-image:linear-gradient(var(--navy),var(--navy));
  background-size:0 1px;background-repeat:no-repeat;background-position:0 100%;
  transition:background-size .3s var(--ease-out),color .2s;
}
.link:hover{background-size:100% 1px}

/* ------------------------------ 首页 ------------------------------ */
.hero{position:relative;padding:64px 0 0;overflow:hidden}
.hero-bg{position:absolute;inset:0;pointer-events:none}
.hero-bg::before{
  content:"";position:absolute;inset:0;
  background-image:linear-gradient(90deg,transparent 0,transparent calc(100% - 1px),var(--hair) 100%);
  background-size:82px 100%;
  opacity:.5;
  mask-image:linear-gradient(180deg,rgba(0,0,0,.9),transparent 88%);
  -webkit-mask-image:linear-gradient(180deg,rgba(0,0,0,.9),transparent 88%);
}
.hero-grid{display:grid;grid-template-columns:minmax(0,1.55fr) minmax(0,1fr);gap:64px;align-items:start}
.hero h1{
  font-family:var(--serif);font-size:var(--t-hero);line-height:1.16;
  letter-spacing:-.02em;margin:0;font-weight:600;
}
.hero h1 .l{display:block;overflow:hidden}
.hero h1 .l > span{display:inline-block;animation:rise .9s var(--ease-out) both}
.hero h1 .l:nth-child(2) > span{animation-delay:.08s}
@keyframes rise{from{transform:translateY(104%);opacity:0}to{transform:translateY(0);opacity:1}}
.hero .lede{margin:24px 0 0;font-size:15.5px;line-height:1.95;color:#3B4B64;max-width:52ch}
.hero-actions{display:flex;align-items:center;gap:26px;margin-top:30px;flex-wrap:wrap}
.hero-search{
  margin-top:34px;display:flex;align-items:center;max-width:480px;
  border-bottom:1px solid var(--sky);transition:border-color .2s;
}
.hero-search:focus-within{border-color:var(--navy)}
.hero-search input{
  flex:1;height:48px;border:0;background:transparent;outline:none;
  font-size:14.5px;color:var(--ink);
}
.hero-search input::placeholder{color:var(--faint)}
.hero-search button{font-size:13px;color:var(--navy);padding:0 2px 0 16px;height:48px;font-weight:600}

/* 右侧：八个维度（数据底座），竖线随载入绘制 */
.rail{border-top:2px solid var(--navy);padding-top:14px;position:relative;max-width:392px;margin-left:auto;width:100%}
.rail-title{font-size:12px;color:var(--muted);margin:0 0 2px}
.rail-list{list-style:none;margin:12px 0 0;padding:0;position:relative}
.rail-list::before{
  content:"";position:absolute;left:0;top:0;bottom:0;width:1px;background:var(--hair);
  transform:scaleY(0);transform-origin:top;animation:draw 1.1s .25s var(--ease-out) forwards;
}
@keyframes draw{to{transform:scaleY(1)}}
.rail-list li{
  display:grid;grid-template-columns:1fr auto;gap:10px;align-items:baseline;
  padding:9px 0 9px 16px;border-bottom:1px solid #EFF4F9;font-size:13px;color:#33455F;
  position:relative;
}
.rail-list li::before{
  content:"";position:absolute;left:0;top:50%;width:7px;height:1px;background:var(--sky);
}
.rail-list li:last-child{border-bottom:0}
.rail-list b{font-family:var(--mono);font-size:12px;color:var(--navy);font-weight:500;font-variant-numeric:tabular-nums}

/* 收录事实（一句式，不用指标卡） */
.record{
  margin-top:56px;padding-top:22px;border-top:1px solid var(--ink);
  font-family:var(--serif);font-size:clamp(16px,1.6vw,20px);line-height:1.9;color:#33455F;
}
.record b{color:var(--navy);font-weight:600;font-size:1.28em;padding:0 2px;font-variant-numeric:tabular-nums}
.record .sep{color:var(--sky);padding:0 8px}

/* ------------------------------ 知识库条目（列表式，不是卡片） ------------------------------ */
.kb-list{border-top:1px solid var(--hair)}
.kb-item{
  display:grid;grid-template-columns:minmax(0,1fr) 96px;
  gap:40px;align-items:center;padding:24px 4px;border-bottom:1px solid var(--hair);
  position:relative;transition:background .2s var(--ease),padding-left .3s var(--ease-out);
}
.kb-item:hover{background:var(--wash);padding-left:16px}
.kb-item h3{
  font-family:var(--serif);font-size:26px;margin:0;font-weight:600;letter-spacing:-.01em;
  display:flex;align-items:baseline;gap:12px;flex-wrap:wrap;
}
.kb-item h3 small{font-family:var(--serif);font-style:italic;font-size:13px;color:var(--faint);font-weight:400}
.kb-item .facts-line{display:flex;gap:20px;flex-wrap:wrap;font-size:12.5px;color:var(--muted);margin-top:8px}
.kb-item > .facts-line{justify-content:flex-end;margin-top:0}
.kb-item .facts-line span b{color:var(--ink);font-weight:600;font-variant-numeric:tabular-nums}
.kb-item .formula{font-family:var(--mono);font-size:12.5px;color:var(--muted)}
.kb-item .go{font-size:13px;color:var(--navy);white-space:nowrap;opacity:.75;transition:opacity .2s}
.kb-item:hover .go{opacity:1}

/* ------------------------------ 维度列表（浏览/关于共用） ------------------------------ */
.dims{border-top:1px solid var(--hair)}
.dim{
  display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.1fr) auto;gap:24px;
  align-items:baseline;padding:16px 4px;border-bottom:1px solid var(--hair);
  transition:background .2s var(--ease),padding-left .28s var(--ease-out);
}
.dim:hover{background:var(--wash);padding-left:14px}
.dim .name{font-family:var(--serif);font-size:17px;font-weight:600}
.dim .tables{font-family:var(--mono);font-size:11.5px;color:var(--faint)}
.dim .n{font-family:var(--mono);font-size:12px;color:var(--navy);text-align:right}

/* ------------------------------ 模型工作台 ------------------------------ */
.model-group{margin-bottom:44px}
.model-group > h3{
  font-family:var(--serif);font-size:17px;font-weight:600;margin:0 0 2px;
  display:flex;align-items:baseline;gap:12px;
}
.model-group > h3 span{font-family:var(--sans);font-size:12px;color:var(--faint);font-weight:400}
.model-rows{border-top:1px solid var(--hair);margin-top:12px}
.model-row{
  display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.35fr) 168px;
  gap:32px;align-items:baseline;padding:16px 4px;border-bottom:1px solid var(--hair);
  transition:background .2s var(--ease),padding-left .28s var(--ease-out);
}
.model-row:hover{background:var(--wash);padding-left:14px}
.model-row .nm{font-family:var(--serif);font-size:17px;font-weight:600;line-height:1.5}
.model-row .nm em{display:block;font-style:normal;font-size:12px;color:var(--faint);font-family:var(--sans);margin-top:3px}
.model-row .nm em.tbl{font-family:var(--mono);font-size:11.5px;color:var(--faint)}
.model-row .io b{display:inline-block;min-width:34px}
.model-row .io{font-size:12.5px;color:var(--muted);line-height:1.75}
.model-row .io b{color:var(--faint);font-weight:500}
.model-row .side{text-align:right;white-space:nowrap}
.model-row .side .st{font-size:11.5px;color:var(--muted);display:inline-flex;align-items:center;gap:6px}
.model-row .side .st::before{content:"";width:5px;height:5px;border-radius:50%;background:var(--sky)}
.model-row .side .st.dev::before{background:var(--blue)}
.model-row .side .st.live::before{background:#2E9E6B}
.model-row .side .own{display:block;font-size:11px;color:var(--faint);margin-top:3px}

.filter-bar{display:flex;gap:4px;flex-wrap:wrap;margin-bottom:30px;border-bottom:1px solid var(--hair)}
.filter-chip{
  font-size:13px;padding:9px 14px;color:var(--muted);border-bottom:1px solid transparent;
  margin-bottom:-1px;transition:color .2s,border-color .2s;
}
.filter-chip:hover{color:var(--ink)}
.filter-chip.active{color:var(--navy);border-bottom-color:var(--navy);font-weight:600}

/* ------------------------------ 浏览 ------------------------------ */
.toolbar{display:flex;gap:2px;flex-wrap:wrap;margin-bottom:26px;border-bottom:1px solid var(--hair)}
.tab{
  font-size:13px;padding:10px 13px;color:var(--muted);border-bottom:1px solid transparent;
  margin-bottom:-1px;transition:color .2s,border-color .2s;
}
.tab:hover{color:var(--ink)}
.tab.active{color:var(--navy);border-bottom-color:var(--navy);font-weight:600}

/* ------------------------------ 表格 ------------------------------ */
.table-wrap{overflow-x:auto;border-top:1px solid var(--ink)}
table{width:100%;border-collapse:collapse;font-size:13px}
thead th{
  text-align:left;padding:11px 14px;background:transparent;
  font-size:11.5px;color:var(--muted);font-weight:600;white-space:nowrap;
  border-bottom:1px solid var(--hair);
}
tbody td{padding:12px 14px;border-bottom:1px solid #EFF4F9;vertical-align:top;color:#2E3F5C}
tbody tr:last-child td{border-bottom:0}
tbody tr{transition:background .16s var(--ease)}
tbody tr:hover{background:var(--wash)}
td.id,th.id{font-family:var(--mono);font-size:11.5px;color:var(--faint);white-space:nowrap}
tbody td{white-space:nowrap}
tbody td.wrap{white-space:normal;min-width:220px}
tbody td a{color:var(--blue);border-bottom:1px solid rgba(56,121,201,.25);transition:border-color .18s,color .18s}
tbody td a:hover{color:var(--navy);border-bottom-color:var(--navy)}

.domain{margin-bottom:32px}
.domain-head{display:flex;align-items:baseline;gap:12px;margin-bottom:10px}
.domain-head .no{font-family:var(--mono);font-size:11px;color:var(--faint)}
.domain-head h3{font-family:var(--serif);font-size:18px;margin:0;font-weight:600}
.domain-head .count{margin-left:auto;font-size:11.5px;color:var(--faint);font-family:var(--mono)}

/* ------------------------------ 详情 ------------------------------ */
.drug-head{padding:28px 0 34px;border-bottom:1px solid var(--ink)}
.drug-head .row{display:flex;align-items:flex-start;justify-content:space-between;gap:30px;flex-wrap:wrap}
.drug-head h1{font-family:var(--serif);font-size:clamp(30px,3.6vw,42px);margin:0;font-weight:600;letter-spacing:-.015em;line-height:1.25}
.drug-head .en{font-family:var(--serif);font-style:italic;color:var(--faint);font-size:15px;margin-top:6px}
.chips{display:flex;gap:6px;flex-wrap:wrap;margin-top:18px}
.chip{
  font-size:11.5px;color:var(--muted);border:1px solid var(--hair);padding:3px 9px;
  background:var(--white);display:inline-flex;gap:7px;align-items:center;
}
.chip b{color:var(--faint);font-weight:500;font-size:10.5px}
.facts{display:grid;grid-template-columns:repeat(4,1fr);margin-top:28px;border-top:1px solid var(--hair);border-bottom:1px solid var(--hair)}
.fact{padding:16px 18px 15px;border-right:1px solid var(--hair)}
.fact:last-child{border-right:0}
.fact span{display:block;font-size:11px;color:var(--faint);margin-bottom:5px}
.fact b{font-family:var(--serif);font-size:18px;font-weight:600;letter-spacing:-.01em}

.dl{display:grid;grid-template-columns:112px 1fr;margin:0;font-size:13.5px}
.dl dt{padding:10px 0;color:var(--muted);font-size:12.5px;border-bottom:1px solid #F1F5FA}
.dl dd{margin:0;padding:10px 0;border-bottom:1px solid #F1F5FA;color:#2E3F5C;min-width:0;overflow-wrap:anywhere}
code{font-family:var(--mono);font-size:12px;background:var(--wash);padding:2px 6px;color:#2A3A55}
a.ext{color:var(--blue);border-bottom:1px dotted var(--sky);white-space:nowrap}
a.ext:hover{color:var(--navy);border-bottom-color:var(--blue)}
a.ext::after{content:"↗";font-size:9px;margin-left:2px;vertical-align:super;opacity:.7}

.src-list{list-style:none;padding:0;margin:0;border-top:1px solid var(--hair)}
.src-list li{display:grid;grid-template-columns:88px 1fr auto;gap:16px;align-items:baseline;padding:12px 0;border-bottom:1px solid var(--hair);font-size:13px}
.src-list .code{font-family:var(--mono);font-size:11.5px;color:var(--faint)}
.src-list .t{color:#2E3F5C}
.src-list .lv{font-size:11px;color:var(--faint);white-space:nowrap}

.page-head{display:grid;grid-template-columns:minmax(0,1fr) 320px;gap:64px;align-items:end;padding:36px 0 0}
.page-head h1{font-family:var(--serif);font-size:clamp(28px,3.2vw,38px);margin:0;font-weight:600;letter-spacing:-.015em;line-height:1.3}
.page-head .intro{margin:18px 0 0;color:#3B4B64;line-height:1.95;max-width:64ch;font-size:15px}
.stage{border-top:2px solid var(--navy);padding-top:14px}
.stage dl{display:grid;grid-template-columns:1fr auto;gap:9px;margin:0;font-size:13px}
.stage dt{color:var(--muted)}
.stage dd{margin:0;font-family:var(--mono);font-size:12.5px;color:var(--navy);text-align:right}

/* ------------------------------ 结构式 ------------------------------ */
.struct{
  display:grid;grid-template-columns:minmax(0,420px) 1fr;gap:44px;align-items:center;
  border:1px solid var(--hair);padding:28px 30px;background:var(--white);
}
.struct-svg{min-height:180px}
.struct-svg svg{width:100%;height:auto;display:block}
.struct-side .dl{grid-template-columns:92px 1fr}
.struct-actions{margin-top:18px;display:flex;gap:10px;flex-wrap:wrap;align-items:center}
.imp-block{margin-top:24px}
.imp-block h4{font-size:12px;color:var(--muted);margin:0 0 12px;font-weight:400}
.imp-row{display:flex;gap:14px;flex-wrap:wrap}
.imp-card{border:1px solid var(--hair);padding:12px 14px 10px;width:170px;background:var(--white)}
.imp-card svg{width:100%;height:94px;display:block}
.imp-card b{display:block;font-size:12px;margin-top:6px;font-weight:600}
.imp-card span{display:block;font-size:11px;color:var(--faint);font-family:var(--mono)}

.mol-wall{display:grid;grid-template-columns:repeat(4,1fr);gap:14px}
.mol-card{border:1px solid var(--hair);padding:14px;background:var(--white);display:block;position:relative;transition:border-color .2s}
.mol-card:hover{border-color:var(--sky)}
.mol-badge{position:absolute;top:12px;left:14px;font-size:10px;color:var(--blue);border:1px solid var(--sky);padding:0 5px;background:var(--white)}
.mol-figure{height:144px;display:flex;align-items:center;justify-content:center;padding-top:14px}
.mol-figure svg{width:100%;height:100%}
.mol-meta{border-top:1px solid var(--hair);padding-top:10px;margin-top:8px}
.mol-meta b{display:block;font-size:13px;font-weight:600}
.mol-meta span{display:block;font-family:var(--mono);font-size:11px;color:var(--faint)}
.mol-meta em{display:block;font-style:normal;font-size:11px;color:var(--blue);margin-top:2px}

/* ------------------------------ 图谱 ------------------------------ */
#graph{width:100%;height:min(70vh,640px);border:1px solid var(--hair);background:var(--white)}
.legend{display:flex;gap:20px;flex-wrap:wrap;margin-top:14px;font-size:12px;color:var(--muted);align-items:center}
.legend span{display:flex;align-items:center;gap:6px}
.legend i{width:7px;height:7px;display:block;border-radius:50%}

/* ------------------------------ 数据下载 ------------------------------ */
.dl-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}
.dl-item{
  border:1px solid var(--hair);padding:20px;background:var(--white);
  display:flex;align-items:center;gap:14px;justify-content:space-between;
  transition:border-color .2s;
}
.dl-item:hover{border-color:var(--sky)}
.dl-item span{font-size:13px;color:#2E3F5C;line-height:1.5}
.dl-item small{display:block;color:var(--faint);font-size:11px;margin-top:3px}
.dl-item b{font-family:var(--serif);font-size:24px;color:var(--navy);font-weight:600;font-variant-numeric:tabular-nums}

/* ------------------------------ 页脚 ------------------------------ */
.footer{margin-top:100px;border-top:1px solid var(--hair);background:var(--white)}
.footer-inner{width:min(1180px,calc(100% - 56px));margin-inline:auto;padding:48px 0 30px}
.foot-top{display:grid;grid-template-columns:1fr auto;gap:56px;align-items:start}
.foot-brand strong{font-family:var(--serif);font-size:16px;font-weight:600;display:block}
.foot-brand p{margin:8px 0 0;font-size:12px;color:var(--muted);line-height:1.8}
.foot-nav{display:flex;flex-direction:column;gap:8px}
.foot-nav a{font-size:12.5px;color:var(--muted);transition:color .18s}
.foot-nav a:hover{color:var(--navy)}
.foot-orgs{display:flex;gap:18px;align-items:center;margin-top:22px}
.foot-orgs img{height:36px;width:auto;opacity:.62;filter:grayscale(1);transition:opacity .3s,filter .3s}
.foot-orgs img:hover{opacity:1;filter:none}
.foot-bottom{
  display:flex;justify-content:space-between;gap:18px;flex-wrap:wrap;
  margin-top:34px;padding-top:18px;border-top:1px solid var(--hair);
  font-size:11.5px;color:var(--faint);
}

/* ------------------------------ 动效 ------------------------------ */
.page-enter{animation:pageIn .45s var(--ease-out) both}
@keyframes pageIn{from{opacity:0;transform:translateY(6px)}to{opacity:1;transform:none}}
[data-num]{font-variant-numeric:tabular-nums}

@media (prefers-reduced-motion:reduce){
  *,*::before,*::after{animation-duration:.001ms!important;animation-iteration-count:1!important;transition-duration:.001ms!important}
}

/* ------------------------------ 响应式 ------------------------------ */
@media (max-width:1100px){
  .hero-grid{grid-template-columns:1fr;gap:44px}
  .rail{max-width:560px}
  .mol-wall{grid-template-columns:repeat(3,1fr)}
}
@media (max-width:900px){
  .wrap{width:calc(100% - 40px)}
  .section{padding:64px 0}
  .topbar-inner{height:62px;gap:12px}
  .org{height:32px}
  .org-sep{height:22px}
  .brand-text strong{font-size:14px}
  .brand-text em{display:none}
  .nav{
    position:fixed;top:62px;left:0;right:0;background:var(--white);
    flex-direction:column;align-items:stretch;gap:0;padding:6px 0;
    border-bottom:1px solid var(--hair);
    transform:translateY(-130%);transition:transform .32s var(--ease-out);
  }
  .nav.open{transform:none}
  .nav a{padding:13px 22px;font-size:14px;border-bottom:1px solid #F3F7FB}
  .nav a::after{display:none}
  .nav-toggle{display:block;margin-left:auto}
  .search input{width:132px}
  .search input:focus{width:160px}
  .hero{padding-top:44px}
  .section-head{flex-direction:column;align-items:flex-start;gap:10px}
  .section-head p{text-align:left;max-width:100%}
  .kb-item{grid-template-columns:1fr auto;gap:14px}
  .kb-item .facts-line{grid-column:1/-1}
  .model-row{grid-template-columns:1fr;gap:8px}
  .model-row .side{text-align:left}
  .dim{grid-template-columns:1fr auto;gap:8px}
  .dim .tables{grid-column:1/-1}
  .drug-head .row{flex-direction:column}
  .facts{grid-template-columns:repeat(2,1fr)}
  .fact:nth-child(2){border-right:0}
  .fact:nth-child(-n+2){border-bottom:1px solid var(--hair)}
  .dl{grid-template-columns:92px 1fr}
  .struct{grid-template-columns:1fr;gap:26px;padding:22px}
  .dl-grid{grid-template-columns:1fr}
  .foot-top{grid-template-columns:1fr;gap:24px}
  .foot-orgs{order:-1}
  .src-list li{grid-template-columns:1fr;gap:3px}
  .mol-wall{grid-template-columns:repeat(2,1fr)}
}
@media (max-width:600px){
  .wrap{width:calc(100% - 32px)}
  .hero .lede,.page-head .intro,.note,.prose,.record{max-width:100%}
  .hero-search{max-width:100%}
  .rail{max-width:100%}
  .entry,.kb-item{padding-left:0}
  .topbar-inner{gap:8px}
  .hero h1{font-size:clamp(28px,7.6vw,38px)}
  .search{display:none}
  .mol-wall{grid-template-columns:1fr}
  .foot-bottom{flex-direction:column;gap:4px}
  .record{font-size:15px}
}


/* 备案信息 */
.foot-icp {
  margin-top: 10px;
  font-size: 12px;
  color: var(--ink-3, #6b7a8f);
}
.foot-icp a {
  color: inherit;
  text-decoration: none;
  border-bottom: 1px solid transparent;
}
.foot-icp a:hover {
  color: var(--blue-700, #1F4D9A);
  border-bottom-color: currentColor;
}


/* ---------- 卡片式记录列表（无横向滚动） ---------- */
.card-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(300px, 1fr));
  gap: 14px;
  margin-top: 8px;
}
.rec-card {
  min-width: 0;
  border: 1px solid var(--line, #E3EAF2);
  border-radius: 10px;
  background: #fff;
  padding: 16px 18px 18px;
  display: flex;
  flex-direction: column;
  transition: border-color .18s ease, box-shadow .18s ease;
}
.rec-card:hover {
  border-color: var(--blue-300, #B7D2E8);
  box-shadow: 0 2px 10px rgba(31, 77, 154, .07);
}
.rec-head { margin-bottom: 6px; }
.rec-id {
  font-family: ui-monospace, Menlo, Consolas, monospace;
  font-size: 11.5px;
  letter-spacing: .03em;
  color: var(--blue-700, #1F4D9A);
  text-decoration: none;
  word-break: break-all;
}
a.rec-id:hover { text-decoration: underline; }
.rec-title {
  margin: 0 0 10px;
  font-size: 15px;
  line-height: 1.45;
  font-weight: 600;
  color: var(--ink, #16233A);
  overflow-wrap: anywhere;
  word-break: break-word;
}
.rec-fields {
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 7px;
}
.rec-fields > div {
  display: grid;
  grid-template-columns: 88px minmax(0, 1fr);
  gap: 10px;
  font-size: 12.5px;
  line-height: 1.55;
}
.rec-fields dt {
  color: var(--muted, #6B7A8F);
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
}
.rec-fields dd {
  margin: 0;
  min-width: 0;
  color: var(--ink-2, #3A4A5F);
  overflow-wrap: anywhere;
  word-break: break-word;
}
@media (max-width: 720px) {
  .card-grid { grid-template-columns: 1fr; gap: 12px; }
  .rec-fields > div { grid-template-columns: 76px minmax(0, 1fr); }
}


/* ---------- 索引栏（检索 + 分组导航） ---------- */
.idx-wrap { margin-top: 6px; }
.idx-toolbar {
  display: flex; align-items: center; gap: 14px; flex-wrap: wrap;
  padding: 12px 0 14px;
  border-bottom: 1px solid var(--line, #E3EAF2);
}
.idx-search {
  flex: 1 1 260px; min-width: 200px;
  height: 38px; padding: 0 14px;
  border: 1px solid var(--line, #E3EAF2); border-radius: 8px;
  font-size: 13.5px; color: var(--ink, #16233A);
  background: #fff; outline: none;
  transition: border-color .18s ease, box-shadow .18s ease;
}
.idx-search:focus {
  border-color: var(--blue-500, #3879C9);
  box-shadow: 0 0 0 3px rgba(56, 121, 201, .12);
}
.idx-count {
  font-size: 12.5px; color: var(--muted, #6B7A8F);
  white-space: nowrap; font-variant-numeric: tabular-nums;
}
.idx-nav {
  position: sticky; top: 56px; z-index: 5;
  display: flex; gap: 6px; flex-wrap: wrap;
  padding: 12px 0;
  margin-bottom: 4px;
  background: rgba(255, 255, 255, .92);
  backdrop-filter: saturate(1.4) blur(6px);
  border-bottom: 1px solid var(--line, #E3EAF2);
}
.idx-nav a {
  min-width: 28px; height: 26px; padding: 0 9px;
  display: inline-flex; align-items: center; justify-content: center;
  border: 1px solid var(--line, #E3EAF2); border-radius: 6px;
  font-size: 12px; color: var(--ink-2, #3A4A5F);
  text-decoration: none; background: #fff;
  transition: all .15s ease;
}
.idx-nav a:hover {
  border-color: var(--blue-500, #3879C9);
  color: var(--blue-700, #1F4D9A);
  background: var(--blue-50, #F4F8FC);
}
.idx-group { scroll-margin-top: 110px; margin-top: 26px; }
.idx-letter {
  display: flex; align-items: center; gap: 8px;
  margin: 0 0 12px; padding-bottom: 8px;
  border-bottom: 1px solid var(--line-soft, #EFF4F9);
  font-size: 13px; font-weight: 600; color: var(--blue-700, #1F4D9A);
}
.idx-letter em {
  font-style: normal; font-size: 11.5px; font-weight: 400;
  color: var(--muted, #6B7A8F);
  padding: 1px 7px; border-radius: 10px;
  background: var(--blue-50, #F4F8FC);
  font-variant-numeric: tabular-nums;
}
/* 多值标签 */
.chip {
  display: inline-block; margin: 0 4px 4px 0; padding: 2px 8px;
  font-size: 11.5px; line-height: 1.6; border-radius: 4px;
  background: var(--blue-50, #F4F8FC);
  border: 1px solid var(--blue-100, #E1EBF6);
  color: var(--blue-700, #1F4D9A);
  white-space: nowrap;
}
.idx-empty { text-align: center; padding: 40px 0; color: var(--muted); font-size: 13.5px; }
@media (max-width: 720px) {
  .idx-nav { top: 52px; overflow-x: auto; flex-wrap: nowrap; }
  .idx-nav::-webkit-scrollbar { display: none; }
}